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San Francisco to Los Angeles - Sixt One-Way Car Hire

Sixt offers the opportunity of affordable rates on one-way car rental to destinations such as driving from San Francisco to Los Angeles. This service from Sixt allows you the chance and freedom to pick up a rental car in one city and return it to another location. Our deals on one way rental can be great for a thrilling road trip, exploring the west coast at your freedom or continuing a final leg of the journey by flight. For affordable and reliable one-way car hires in the USA - choose Sixt.

Drive between San Francisco & Los Angeles with your one-way car rental

The California coastline is one of the most beautiful, scenic drives in all of the United States. Experience the drive from San Francisco to Los Angeles with great deals and affordable rates from Sixt. With a one-way car rental from Sixt, you can enjoy the unique, differing experience these two California cities offer. With a large available fleet in both cities, you can choose from many models including economy, convertible, 4x4 and luxury hires to fit your travel needs. Don't worry about making a return trip and truly enjoy this one of a kind journey with Sixt rent a car. 

BMW 2 Series Convertible Hire One Way

Convertible Hire USA

Take a fun spirited drive across America in a Sixt convertible hire. The trip through the sunny desert landscapes and thrilling highways from city to city are perfect with the roof down. Sixt offers a large fleet of convertible rental models to make your trip to in the USA one that will be unforgettable.

Chavrolet Tahoe SUV Hire in the USA

4x4 Hire in the USA

Sixt offers a wide range of SUV and 4x4 models to make your drive across the States comfortable and spacious. The drive through the desert in a Sixt 4x4 hire will allow everyone to enjoy the adventure. Sixt has the perfect SUV rental for any and all journeys to make your trip more enjoyable.

Luxury Car Hire in USA with Sixt

Luxury Cars USA

There is no better way to travel across the USA than in a luxury car rental from Sixt. With a large fleet of available exotic cars, you can feel like one of the stars and a high roller all in the same day. Use one of the many luxury and sports cars options from Sixt rent a car to truly stand out on your trip.

Driving Directions from San Francisco to Los Angeles

The drive between San Francisco and Los Angeles is a straight shot down the California coastline. The drive time takes around 6 hours over 400 miles on Interstate 5. Although the drive takes place over a single interstate, there a plenty of stops along the way with interesting sites to see:


  • Stop in the cities of Santa Barbara, Pismo Beach, San Luis Obispo, Salinas, Monterey Bay and Santa Cruz
  • Stop at one of the 21 historic missions representing the first non-Native American settlements in California
  • Boat trips to see humpback, gray and blue whales in Ventura, Oxnard, Santa Barbara, Santa Cruz and Monterey
  • Pinnacles National monument, the remains of the historic, ancient volcano